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The term usually refers to damage induced by excessive use of combinations of these medications, especially combinations that include phenacetin. It may also be used to describe kidney injury from any single analgesic medication. The specific kidney injuries induced by analgesics are renal papillary necrosis and chronic interstitial nephritis.
Dialysis is recommended in those with kidney failure, decreased level of consciousness, blood pH less than 7.2, or high blood salicylate levels. [2] If a person requires intubation, a fast respiratory rate may be required. [1] The toxic effects of salicylates have been described since at least 1877. [5]
This effect may potentially be worsened by high purine diets, diuretics, and kidney disease, but is eliminated by the urate lowering drug allopurinol. [184] Daily low dose aspirin does not appear to worsen kidney function. [185]
Ibuprofen (Advil or Motrin), naproxen (Aleve) and aspirin ... ulcers, or bleeding), increased risk of heart attack and stroke, reduced kidney ... high blood pressure or liver disease. ...
Nephrotoxicity is toxicity in the kidneys.It is a poisonous effect of some substances, both toxic chemicals and medications, on kidney function. [1] There are various forms, [2] and some drugs may affect kidney function in more than one way.
[55] [56] Use of aspirin during dengue fever is not recommended owing to increased bleeding tendency. [57] People with kidney disease, hyperuricemia, or gout should not take aspirin because it inhibits the kidneys' ability to excrete uric acid, and thus may exacerbate these conditions.
A — aspirin; R — renal failure; K — ketoacidosis, ketones generated from starvation, alcohol, and diabetic ketoacidosis; The mnemonic MUDPILES is commonly used to remember the causes of increased anion gap metabolic acidosis. [5] [6] M — Methanol; U — Uremia (chronic kidney failure) D — Diabetic ketoacidosis
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