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Metformin does not cause kidney damage by itself, however there is a risk of serious side effects if metformin is used when you have impaired renal function, Dr. Gupta notes.
This may happen if you’re not eating enough food, are drinking alcohol, or are taking other medications to lower blood glucose. It’s uncommon, but there is also a risk of lactic acidosis when ...
Metformin can also be useful for those with prediabetes — this is when you have high blood sugar levels, but they’re not yet high enough to diagnose type 2 diabetes.
[37] [40] A 2020 Cochrane systematic review did not find enough evidence of reduction of cardiovascular mortality, non-fatal myocardial infarction or non-fatal stroke when comparing metformin monotherapy to other glucose-lowering drugs, behavior change interventions, placebo or no intervention. [41]
In those with prediabetes, metformin may delay or reduce the risk of developing type 2 diabetes compared to diet and exercise or a placebo intervention, but not compared to intensive diet and exercise, and there was not enough data on outcomes such as mortality and diabetic complications and health-related quality of life, according to a 2019 ...
One review found that those who took 2.55 grams of metformin a day lost about 13 pounds over 28 weeks. That’s about half a pound a week. However, metformin is typically prescribed in lower doses ...