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A significant risk of megaloblastic anaemia exists with doses of pyrimethamine in excess of 25 mg/wk. Antivirals, more specifically, lamivudine (increased plasma concentrations of lamivudine), zalcitabine (increased plasma concentrations of zalcitabine) and zidovudine (increased risk of haematological reactions)
However, the half-life of the drug noticeably increases in people with creatinine clearance rates equal to or less than 30 mL/minute. A half-life of 22–50 hours has been reported for people with creatinine clearances of less than 10 mL/minute. [11] Metabolism. Sulfamethoxazole is metabolized in the human liver to at least 5 metabolites.
Linezolid is an antibiotic used for the treatment of infections caused by Gram-positive bacteria that are resistant to other antibiotics. [9] [10] Linezolid is active against most Gram-positive bacteria that cause disease, including streptococci, vancomycin-resistant enterococci (VRE), and methicillin-resistant Staphylococcus aureus (MRSA).
They are small (0.5 to 0.7 by 0.6 to 1.5 μm), non-encapsulated, non-motile, [4] facultatively intracellular coccobacilli. Brucella spp. are the cause of brucellosis , which is a zoonosis transmitted by ingesting contaminated food (such as unpasteurized milk products), direct contact with an infected animal, or inhalation of aerosols.
Brucellosis [4] is a zoonosis caused by ingestion of unpasteurized milk from infected animals, or close contact with their secretions. [5] It is also known as undulant fever, Malta fever, and Mediterranean fever. [6] The bacteria causing this disease, Brucella, are small, Gram-negative, nonmotile, nonspore-forming, rod-shaped (coccobacilli ...
Brucella melitensis is a Gram-negative coccobacillus bacterium from the Brucellaceae family. The bacterium causes ovine brucellosis , along with Brucella ovis . Humans can become infected if they have contact with an infected animal or its byproducts.
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