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The central dogma of molecular biology deals with the flow of genetic information within a biological system. It is often stated as "DNA makes RNA, and RNA makes protein", [1] although this is not its original meaning. It was first stated by Francis Crick in 1957, [2] [3] then published in 1958: [4] [5] The Central Dogma.
Dogma, in its broadest sense, is any belief held definitively and without the possibility of reform.It may be in the form of an official system of principles or doctrines of a religion, such as Judaism, Roman Catholicism, Protestantism, [1] or Islam, the positions of a philosopher or philosophical school, such as Stoicism, and political belief systems such as fascism, socialism, progressivism ...
The extended central dogma of molecular biology includes all the processes involved in the flow of genetic information. Main article: Gene expression Gene expression is the molecular process by which a genotype encoded in DNA gives rise to an observable phenotype in the proteins of an organism's body.
Analogous to the nonribosomal code is prediction of peptide composition by DNA/RNA codon reading, which is well supported by the central dogma of molecular biology and accomplished using the genetic code simply by following the DNA codon table or RNA codon table. However, prediction of natural product/secondary metabolites by the nonribosomal ...
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The term "retro" in retrovirus refers to this reversal (making DNA from RNA) of the usual direction of transcription. It still obeys the central dogma of molecular biology , which states that information can be transferred from nucleic acid to nucleic acid but cannot be transferred back from protein to either protein or nucleic acid.
Yet 25 years on, Dogma is not available on any streaming service and last received a physical release when it came out on Blu-ray in 2008. DVDs and VHS copies now change hands for inflated sums ...
The Russian biologist and historian Zhores A. Medvedev, reviewing Weismann's theory a century later, considered that the accuracy of genome replicative and other synthetic systems alone could not explain the "immortal" germ cell lineages proposed by Weismann.