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In 2021, there were 710,151 diagnosed cases of gonorrhea, a 28% increase since 2017, according to the Centers for Disease Control and Prevention. Gonorrhea spreads through sexual contact and can ...
As of 2010, the recommended treatment is a single 250 mg intramuscular injection of ceftriaxone, sometimes in combination with azithromycin or doxycycline. [3] [4] However, certain strains of N. gonorrhoeae can be resistant to antibiotics that are normally used to treat it.
Further, a single dose of azithromycin can lead to the bacteria becoming resistant to azithromycin. [48] Among Swedish patients, doxycycline was shown to be relatively ineffective (with a cure rate of 48% for women and 38% for men); and treatment with a single dose of azithromycin is not prescribed due to it inducing antimicrobial resistance.
Following a single dose of 500 mg, the apparent terminal elimination half-life of azithromycin is 68 hours. [8] Biliary excretion of azithromycin, predominantly unchanged, is a major route of elimination. [50] Over the course of a week, about 6% of the administered dose appears as an unchanged drug in urine. [8]
The Canadian report called antibiotic-resistant gonorrhea “a serious public health threat” and said the STI’s ability to withstand two antibiotics used to treat it, ceftriaxone and ...
Although infections like chlamydia, for example, are highest among adolescents and young adults, a new research review presented at the European Congress of Clinical Microbiology and Infectious ...
This occurs in between 0.6 and 3% of infected women and 0.4 and 0.7% of infected men. [19] In men, inflammation of the epididymis, prostate gland, and urethra can result from untreated gonorrhea. [70] In women, the most common result of untreated gonorrhea is pelvic inflammatory disease.
Each drug should be administered as a single dose, with the gentamicin entering intramuscularly at a concentration of 240 mg, along with 2 g of azithromycin taken orally. [79] If an individual is not allergic to cephalosporins but ceftriaxone is unavailable, an alternative treatment is a single dose of 800 mg cefixime consumed orally. [79]