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Clue cells are epithelial cells of the vagina that get their distinctive stippled appearance by being covered with bacteria. The etymology behind the term "clue" cell derives from the original research article from Gardner and Dukes describing the characteristic cells.
The presence of clue cells on wet mount. Similar to the whiff test, the test for clue cells is performed by placing a drop of sodium chloride solution on a slide containing vaginal discharge. If present, clue cells can be visualized under a microscope. They are so-named because they give a clue to the reason behind the discharge.
A vaginal wet mount with a clue cell, indicating bacterial vaginosis. Bacterial vaginosis generally produces a vaginal discharge that is thin and milky with a fishy odor. [1] Diagnosis is made using Amsel Criteria - three of the four following criteria must be met: >20% of the epithelial cells are clue cells (the single most reliable predictor) [4]
The vagina is an important part of the female anatomy, but many people know very little about it. "When we do exams in the office, we get out a mirror, show women their vaginas and point out the ...
Gram stain of cells from the vagina (the same magnification) with normal bacterial flora (top) and the bacteria that cause vaginosis (bottom). A variety of diagnosis techniques are currently available for identifying Gardnerella vaginalis such as the OSOM BV Blue assay, FemExam cards and nucleic acid amplification tests (NAATs), resulting in the determination of ongoing BV.
Normal vaginal discharge is composed of cervical mucus, vaginal fluid, shedding vaginal and cervical cells, and bacteria. [1] The majority of the liquid in vaginal discharge is mucus produced by glands of the cervix. [1] [4] The rest is made up of transudate from the vaginal walls and secretions from glands (Skene's and Bartholin's). [4]
World renowned Austrian neurologist Sigmund Freud introduces his theory on psychosexual development, which asserts that there is an immature clitoral orgasm and a mature vaginal orgasm. He states that the clitoris is the site for pre-pubescent orgasms but upon reaching puberty, healthy women should begin having vaginal orgasms instead.
To diagnose BV in a clinical setting, an Amsel's criteria is used. This means that a patient must have an increased homogeneous thin vaginal discharge, pH secretion higher than 4.5, amine odor when secretions are exposed to hydroxide 10% solution, or clue cells visible on a wet mount.