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They are located behind the peritoneum (retroperitoneally) [6] on the back wall of the body. [7] The typical mammalian kidney consists of a renal capsule, a peripheral cortex, an internal medulla, one or more renal calyces, and a renal pelvis. [7] Although the calyces or renal pelvis may be absent in some species. [7]
Nephrin is a zipper-like protein that forms the slit diaphragm, with spaces between the teeth of the zipper big enough to allow sugar and water through but too small to allow proteins through. Nephrin defects are responsible for congenital kidney failure. CD2AP regulates the podocyte cytoskeleton and stabilizes the slit diaphragm. [4] [5]
The reniculate kidney is a multilobed kidney found in marine and aquatic mammals such as pinnipeds (seals, sea lions and walruses) and cetaceans (dolphins and whales) but absent in terrestrial mammals except bears. [1] Kidneys of this morphology have increased surface area for removing toxins from the body more efficiently than a non-lobed kidney.
The juxtaglomerular apparatus is part of the kidney nephron, next to the glomerulus. It is found between afferent arteriole and the thick ascending limb of the loop of Henle (distal straight tubule) of the same nephron. This location is critical to its function in regulating renal blood flow and glomerular filtration rate. [2] [3]
Renal physiology (Latin renes, "kidneys") is the study of the physiology of the kidney. This encompasses all functions of the kidney, including maintenance of acid-base balance; regulation of fluid balance; regulation of sodium, potassium, and other electrolytes; clearance of toxins; absorption of glucose, amino acids, and other small molecules ...
The medical history takes into account present and past symptoms, especially those of kidney disease; recent infections; exposure to substances toxic to the kidney; and family history of kidney disease. Kidney function is tested by using blood tests and urine tests. The most common blood tests are creatinine, urea and electrolytes.
In mammals, the kidneys are usually bean-shaped [58] and located retroperitoneally [59] on the dorsal (posterior) wall of the body. [60] The outer layer of each kidney is made up of a fibrous sheath called the renal capsule. The peripheral layer of the kidney is called the cortex and the inner part is called the medulla. The medulla consists of ...
The collecting duct system is the final component of the kidney to influence the body's electrolyte and fluid balance. In humans, the system accounts for 4–5% of the kidney's reabsorption of sodium and 5% of the kidney's reabsorption of water. At times of extreme dehydration, over 24% of the filtered water may be reabsorbed in the collecting ...