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The blood–CSF boundary at the choroid plexus is a membrane composed of epithelial cells and tight junctions that link them. [14] There is a CSF-brain barrier at the level of the pia mater, but only in the embryo. [15] Similar to the blood–brain barrier, the blood–CSF barrier functions to prevent the passage of most blood-borne substances ...
The blood–brain barrier (BBB) is a highly selective semipermeable border of endothelial cells that regulates the transfer of solutes and chemicals between the circulatory system and the central nervous system, thus protecting the brain from harmful or unwanted substances in the blood. [1]
The ependyma is made up of ependymal cells called ependymocytes, a type of glial cell. These cells line the ventricles in the brain and the central canal of the spinal cord, which become filled with cerebrospinal fluid. These are nervous tissue cells with simple columnar shape, much like that of some mucosal epithelial cells. [2]
The blood-brain barrier and the blood-spinal cord barrier: Pericytes and astrocytes endfeet (Astrocytic endfeet envelop the abluminal surface of brain capillaries, accounting for 70% to nearly 100% of their total surface area). [34] The inner blood retinal barrier (iBRB) [35] Pericytes and endfeet of glial cells like astrocytes and Müller cells.
The cerebrospinal fluid (CSF) within the skull and spine provides further protection and also buoyancy, and is found in the subarachnoid space between the pia mater and the arachnoid mater. [citation needed] The CSF that is produced in the ventricular system is also necessary for chemical stability, and the provision of nutrients needed by the ...
Studies suggests that tanycyte cells bridge the gap between the central nervous system (CNS) via cerebrospinal fluid (CSF) to the hypophyseal portal blood. [8] [9] Tanycytes provide a link that is both structural and functional between the CSF and the perivascular space of the hypophyseal portal vessels. [3]
The cranial pia mater joins with the ependyma, which lines the cerebral ventricles to form choroid plexuses that produce cerebrospinal fluid. Together with the other meningeal layers, the function of the pia mater is to protect the central nervous system by containing the cerebrospinal fluid, which cushions the brain and spine. [7]
Tight epithelia have tight junctions that prevent most movement between cells. Examples of tight epithelia include the distal convoluted tubule, the collecting duct of the nephron in the kidney, and the bile ducts ramifying through liver tissue. Other examples are the blood-brain barrier and the blood cerebrospinal fluid barrier