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Cefadroxil (formerly trademarked as Duricef) is a broad-spectrum antibiotic of the cephalosporin type, effective in Gram-positive and Gram-negative bacterial infections. It is a bactericidal antibiotic. It was patented in 1967 and approved for medical use in 1978. [1]
Bactericidal for both Gram-positive and Gram-negative organisms and therefore useful for empiric broad-spectrum antibacterial coverage. (Notes: MRSA resistance to this class. All are active against Pseudomonas aeruginosa except ertapenem.) Gastrointestinal upset and diarrhea; Nausea; Seizures; Headache; Rash and allergic reactions
Gram-negative: Third-generation cephalosporins have a broad spectrum of activity and further increased activity against gram-negative organisms. They may be particularly useful in treating hospital-acquired infections , although increasing levels of extended-spectrum beta-lactamases are reducing the clinical utility of this class of antibiotics.
β-Lactam antibiotics are indicated for the prevention and treatment of bacterial infections caused by susceptible organisms. At first, β-lactam antibiotics were mainly active only against gram-positive bacteria, yet the recent development of broad-spectrum β-lactam antibiotics active against various gram-negative organisms has increased their usefulness.
They have good antimicrobial activity against gram-positive bacteria but limited activity against gram-negative species. [25] The chemical structures of the first generation cephalosporins are fairly simple. As an example three drugs from this class (cefalexin, cefradine and cefadroxil) all have a single
Cefpodoxime is an oral, third-generation cephalosporin antibiotic available in various generic preparations. It is active against both Gram-positive and Gram-negative organisms with notable exceptions including Pseudomonas aeruginosa, Enterococcus, and Bacteroides fragilis.
For reference, a half-cup serving of canned tomatoes packed in tomato juice with no added salt has just 20 calories and provides 2 grams of fiber, 1 gram of protein, 12 milligrams of sodium and 3 ...
Cefuroxime is active against many bacteria including susceptible strains of Staphylococci and Streptococci, as well as a range of gram negative organisms. [11] As with the other cephalosporins, it is susceptible to beta-lactamase, although as a second-generation variety, it is less so.