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Dantrolene sodium, sold under the brand name Dantrium among others, is a postsynaptic muscle relaxant that lessens excitation-contraction coupling in muscle cells. [ 5 ] [ 6 ] [ 7 ] It achieves this by inhibiting Ca 2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors . [ 8 ]
After the widespread introduction of treatment with dantrolene, the mortality of malignant hyperthermia fell from 80% in the 1960s to less than 5%. [5] Dantrolene remains the only drug known to be effective in the treatment of MH. [30] The recommended dose of dantrolene is 2.5 mg/kg, repeated as necessary. [5]
Package inserts for prescription drugs often include a separate document called a "patient package insert" with information written in plain language intended for the end-user—the person who will take the drug or give the drug to another person, such as a minor.
Chest wall. Wooden chest syndrome is a rigidity of the chest following the administration of high doses of opioids during anesthesia [1]. Wooden chest syndrome describes marked muscle rigidity — especially involving the thoracic and abdominal muscles — that is an occasional adverse effect associated with the intravenous administration of lipophilic synthetic opioids such as fentanyl. [2]
Aaron Rodgers' turbulent run with the New York Jets is meeting an unceremonious end.. As it launches a new era under first-year head coach Aaron Glenn and general manager Darren Mougey, the team ...
The diagnosis is suggested on patients with a history of drug exposure to the most common inducing agents such as strong antidopaminergic medications. [ 6 ] [ 40 ] The differential diagnosis includes serotonin syndrome , [ 41 ] encephalitis , toxic encephalopathy , status epilepticus , heat stroke , catatonia and malignant hyperthermia .
Conductive education (CE) was developed in Hungary from 1945 based on the work of András Pető. It is a unified system of rehabilitation for people with neurological disorders including cerebral palsy, Parkinson's disease and multiple sclerosis, amongst other conditions.
A different study was published in June 2019 that examined the association between hyperthermia in older adults and the temperatures in the United States. Hospitalization records of elderly patients in the US between 1991 and 2006 were analyzed and concluded that cases of hyperthermia were observed to be highest in regions with arid climates.