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Paracetamol (acetaminophen[ a ]) is a non-opioid analgesic and antipyretic agent used to treat fever and mild to moderate pain. [ 14 ][ 15 ][ 16 ] It is a widely used over-the-counter medication. Common brand names include Tylenol and Panadol.
The effect of grapefruit juice with regard to drug absorption was originally discovered in 1989 by a group led by pharmacologist David Bailey. Their first published clinical report on grapefruit drug interactions was in 1991. [9] The effect was first discovered accidentally in 1989, when a test of drug interactions with alcohol used grapefruit ...
Non-steroidal anti-inflammatory drugs[1][3] (NSAID) [1] are members of a therapeutic drug class which reduces pain, [4] decreases inflammation, decreases fever, [1] and prevents blood clots. Side effects depend on the specific drug, its dose and duration of use, but largely include an increased risk of gastrointestinal ulcers and bleeds, heart ...
Other over-the-counter drugs, such as Novartis' Excedrin, J&J's Sudafed, and Bayer 's Alka-Seltzer Cold and Sinus also contain acetaminophen. GSK's Panadol, which is widely available in the U.K ...
CYP3A4. Cytochrome P450 3A4 (abbreviated CYP3A4) (EC 1.14.13.97) is an important enzyme in the body, mainly found in the liver and in the intestine, which in humans is encoded by CYP3A4 gene. It oxidizes small foreign organic molecules (xenobiotics), such as toxins or drugs, so that they can be removed from the body.
A common herbal supplement that interferes with a number of medications is turmeric. Turmeric and its bioactive compound curcumin are recognized for their anti-inflammatory and brain health ...