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  2. History of depression - Wikipedia

    en.wikipedia.org/wiki/History_of_depression

    In the mid-20th century, researchers theorized that depression was caused by a chemical imbalance in neurotransmitters in the brain, a theory based on observations made in the 1950s of the effects of reserpine and isoniazid in altering monoamine neurotransmitter levels and affecting depressive symptoms. [32]

  3. Depression (mood) - Wikipedia

    en.wikipedia.org/wiki/Depression_(mood)

    e. Depression is a mental state of low mood and aversion to activity. [3] It affects about 3.5% of the global population, or about 280 million people of all ages (as of 2020). [4] Depression affects a person's thoughts, behavior, feelings, and sense of well-being. [5]

  4. Major depressive disorder - Wikipedia

    en.wikipedia.org/wiki/Major_depressive_disorder

    Major depressive disorder (MDD), also known as clinical depression, is a mental disorder [ 9 ] characterized by at least two weeks of pervasive low mood, low self-esteem, and loss of interest or pleasure in normally enjoyable activities. Introduced by a group of US clinicians in the mid-1970s, [ 10 ] the term was adopted by the American ...

  5. Biology of depression - Wikipedia

    en.wikipedia.org/wiki/Biology_of_depression

    Biology of depression. Scientific studies have found that different brain areas show altered activity in humans with major depressive disorder (MDD), [ 1 ] and this has encouraged advocates of various theories that seek to identify a biochemical origin of the disease, as opposed to theories that emphasize psychological or situational causes.

  6. Mood disorder - Wikipedia

    en.wikipedia.org/wiki/Mood_disorder

    Family history, previous diagnosis of a mood disorder, trauma, stress or major life changes in the case of depression, physical illness or use of certain medications. Depression has been linked to major diseases such as cancer, diabetes, Parkinson's disease and heart disease, Brain structure and function in the case of bipolar disorder. [1 ...

  7. Great Depression - Wikipedia

    en.wikipedia.org/wiki/Great_Depression

    The Great Depression (1929–1939) was a severe global economic downturn that affected many countries across the world. It became evident after a sharp decline in stock prices in the United States, the largest economy in the world at the time, leading to a period of economic depression. [ 1 ] The economic contagion began around September 1929 ...

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