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Red ears in RP can be bilateral or unilateral, and are described as “earlobe sparing” due to the lack of cartilage in the earlobe. Prolonged inflammation can eventually result in deteriorated ear cartilage (often described as “ cauliflower ear ” or “floppy ear”), and even partial or total loss of hearing.
Frank's sign is a diagonal crease in the ear lobe extending from the tragus across the lobule to the rear edge of the auricle. [1] The sign is named after Sanders T. Frank. [1] It has been hypothesised that Frank's sign is indicative of cardiovascular disease [2] [3] and/or diabetes. [4]
The blood reaching the extremities is not oxygen-rich and when viewed through the skin a combination of factors can lead to the appearance of a blue color. All factors contributing to central cyanosis can also cause peripheral symptoms to appear, but peripheral cyanosis can be observed in the absence of heart or lung failures. [5]
The primary causes include post-cataract surgery, certain medications, and, less commonly, neurological or ophthalmological conditions. Post-cataract surgery is a common cause, as replacing the natural lens with a synthetic one increases exposure to blue light, leading to temporary blue-tinted vision. This effect usually resolves as the eye adapts.
The very term "acrocyanosis" is often applied inappropriately in cases when blue discoloration of the hands, feet, or parts of the face is noted. [1] The principal (primary) form of acrocyanosis is that of a benign cosmetic condition, [ 2 ] sometimes caused by a relatively benign neurohormonal disorder. [ 3 ]
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The "blue men of Lurgan" were a pair of Lurgan men suffering from what was described as "familial idiopathic methemoglobinemia" who were treated by James Deeny in 1942. Deeny, who would later become the Chief Medical Officer of the Republic of Ireland, prescribed a course of ascorbic acid and sodium bicarbonate. In case one, by the eighth day ...
The idea that acetaldehyde is the cause of the flush is also shown by the clinical use of disulfiram (Antabuse), which blocks the removal of acetaldehyde from the body via ALDH inhibition. The high acetaldehyde concentrations described share similarity to symptoms of the flush (flushing of the skin, accelerated heart rate, shortness of breath ...