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In bioinformatics, miRBase is a biological database that acts as an archive of microRNA sequences and annotations. [1] [2] [3] [4] As of September 2010 it contained ...
miRBase: the microRNA database; PolymiRTS: a database of DNA variations in putative microRNA target sites; PolyQ: database of polyglutamine repeats in disease and non-disease associated proteins; Rfam: a database of RNA families; IRESbase: A comprehensive database of experimentally validated internal ribosome entry sites. [14]
database: website [25] miRBase: miRBase database is a searchable database of published miRNA sequences and annotation. database: website [26] microRNA.org: microRNA.org is a database for Experimentally observed microRNA expression patterns and predicted microRNA targets & target downregulation scores. database: website [27] miRGen 4.0
miRBase is considered to be the gold-standard miRNA database—it stores miRNA sequences detected by thousand of experiments. In this database each miRNA is associated with a miRNA precursor and with one or two mature miRNA (-5p and -3p). In the past it had always been said that the same miRNA precursor generates the same miRNA sequences.
Many mammalian genomes encode four closely related miR-29 precursors that are transcribed in two transcriptional units. For example, human miR-29a and miR-29b-1 are processed from an intron of a long non-coding transcript pri-miRNA (lnc-pri-miRNA) LOC646329 from chromosome 7. miR-29b-2 (identical in sequence to miR-29b-1) and miR-29c are co-transcribed from chromosome 1.
The miR-16 microRNA precursor family is a group of related small non-coding RNA genes that regulates gene expression. miR-16, miR-15, mir-195 and miR-497 are related microRNA precursor sequences from the mir-15 gene family ().
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miR-92 is part of a large precursor sequence that forms a stem loop once transcribed into RNA. This long precursor sequence is a component of the mir-17-92 cluster which contains 5 additional mir precursor sequences: mir-17, mir-18a, mir-19a, mir-20a and mir19b-1. [4]