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Fluorouracil (5-FU, 5-fluorouracil), sold under the brand name Adrucil among others, is a cytotoxic chemotherapy medication used to treat cancer. [3] By intravenous injection it is used for treatment of colorectal cancer , oesophageal cancer , stomach cancer , pancreatic cancer , breast cancer , and cervical cancer . [ 3 ]
Fluorodeoxyuridylate, [1] also known as FdUMP, 5-fluoro-2'-deoxyuridylate, and 5-fluoro-2'-deoxyuridine 5'-monophosphate, is a molecule formed in vivo from 5-fluorouracil and 5-fluorodeoxyuridine. FdUMP acts as a suicide inhibitor of thymidylate synthase (TS). By inhibiting the deoxynucleotide biosynthesis, FdUMP stops the rapidly proliferation ...
Fluorouracil (5-FU) Tegafur Some metabolites of these drugs, such as 5-fluorodeoxyuridylate monophosphate , also have fluoropyrimidine structures in the general sense of the term, but the more specific meaning is typically reserved for substances used as pharmaceuticals.
5-Fluoroorotic acid (5FOA) is a fluorinated derivative of the pyrimidine precursor orotic acid. It is used in yeast genetics to select for the absence of the URA3 gene, which encodes the enzyme for the decarboxylation of 5-fluoroorotic acid to 5-fluorouracil , a toxic metabolite. [ 1 ]
Tegafur is a chemotherapeutic prodrug of 5-fluorouracil (5-FU) used in the treatment of cancers. It is a component of the combination drug tegafur/uracil. When metabolised, it becomes 5-FU. [1] It was patented in 1967 and approved for medical use in 1972. [2]
Floxuridine is rapidly catabolized to 5-fluorouracil, which is the active form of the drug. The primary effect is interference with DNA synthesis and to a lesser extent, inhibition of RNA formation through the drug's incorporation into RNA , thus leading to the production of fraudulent RNA.
Thymidylate synthase (TS) (EC 2.1.1.45) [5] is an enzyme that catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP). Thymidine is one of the nucleotides in DNA. With inhibition of TS, an imbalance of deoxynucleotides and increased levels of dUMP arise. Both cause DNA damage. [6] [7]
Flucytosine, also known as 5-fluorocytosine (5-FC), is an antifungal medication. [2] It is specifically used, together with amphotericin B, for serious Candida infections and cryptococcosis. [2] It may be used by itself or with other antifungals for chromomycosis. [2] Flucytosine is used by mouth and by injection into a vein. [2] [3]