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This complex is composed of several proteins – products of the SWI and SNF genes (SWI1, SWI2/SNF2, SWI3, SWI5, SWI6), as well as other polypeptides. [3] It possesses a DNA-stimulated ATPase activity that can destabilize histone -DNA interactions in reconstituted nucleosomes in an ATP -dependent manner, though the exact nature of this ...
57376 Ensembl ENSG00000073584 ENSMUSG00000037935 UniProt Q969G3 O54941 RefSeq (mRNA) NM_003079 NM_020618 RefSeq (protein) NP_003070 NP_003070.3 NP_065643 Location (UCSC) Chr 17: 40.62 – 40.65 Mb Chr 11: 99.1 – 99.12 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 is a protein that in ...
However, the chromatin remodeling activities of ISWI and SWI/SNF are distinct and mediate the binding of non-overlapping sets of DNA transcription factors. [ 3 ] The protein ISW1 is the first ATPase subunit which has been isolated in the ISWI chromatin remodeling family in the fruit fly Drosophila .
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 is a protein in humans that is encoded by the SMARCD2 gene. [5] [6] [7]The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin ...
There are four subfamilies of chromatin remodelers: SWI/SNF, INO80, ISW1, and CHD. [2] The RSC complex is a 15-subunit chromatin remodeling complex initially found in Saccharomyces cerevisiae, and is homologous to the SWI/SNF complex found in humans. [1] The RSC complex has ATPase activity in the presence of DNA. [1]
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 is a protein that in humans is encoded by the SMARCB1 gene. [ 5 ] [ 6 ] [ 7 ] Function
Nutritional genomics, also known as nutrigenomics, is a science studying the relationship between human genome, human nutrition and health. People in the field work toward developing an understanding of how the whole body responds to a food via systems biology, as well as single gene/single food compound relationships.
Cis-regulatory DNA sequences that are located in DNA regions distant from the promoters of genes can have very large effects on gene expression, with some genes undergoing up to 100-fold increased expression due to such a cis-regulatory sequence. [3] These cis-regulatory sequences include enhancers, silencers, insulators and tethering elements. [4]