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grade 1: the cartilage has a soft spot, blisters, or superficial wear; grade 2: minor tears of less than one-half the thickness of the cartilage layer; grade 3: lesions have deep crevices of more than one-half the thickness of the cartilage layer; grade 4: the cartilage tear is full thickness and exposes the underlying (subchondral) bone
Spinal disc herniation: Asymmetrical compression of an intervertebral disc ruptures the sac-like disc, causing a herniation of its soft content. The hernia compresses the adjacent nerves and causes back pain.
The proof of an ongoing pathologic process in a Modic change has been documented by SPECT analysis [Isotope scanning using single positron emission computerized tomography], combined with high-resolution CT imaging. This method has shown high metabolic activity in 96.1% of endplates with Modic change type I and 56% with Modic change type 2. [50]
Chondromalacia patellae (also known as CMP) is an inflammation of the underside of the patella and softening of the cartilage.. The cartilage under the kneecap is a natural shock absorber, and overuse, injury, and many other factors can cause increased deterioration and breakdown of the cartilage.
The disc spaces, facet and sacroiliac joints remain unaffected. Diagnosis requires confluent ossification of at least four contiguous vertebral bodies. [ 2 ] Classically, advanced disease may have "melted candle wax" appearance along the spine on radiographic studies. [ 13 ]
A spotted gar larva at 22 days stained for cartilage (blue) and bone (red). Chondrogenesis is the biological process through which cartilage tissue is formed and developed. . This intricate and tightly regulated cellular differentiation pathway plays a crucial role in skeletal development, as cartilage serves as a fundamental component of the embryonic skele