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The IM formulations of these three atypical antipsychotics are considered to be at least as effective or even more effective than the IM administration of haloperidol alone or haloperidol with lorazepam [15] [16] [17] (which is the standard treatment of agitation in most hospitals) and the atypicals have a dramatically improved tolerability due ...
Haloperidol, sold under the brand name Haldol among others, is a typical antipsychotic medication. [9] Haloperidol is used in the treatment of schizophrenia , tics in Tourette syndrome , mania in bipolar disorder , delirium , agitation, acute psychosis , and hallucinations from alcohol withdrawal .
Typical antipsychotics can be used to treat, e.g., schizophrenia or severe agitation. [5] Haloperidol, due to the availability of a rapid-acting injectable formulation and decades of use, remains the most commonly used antipsychotic for treating severe agitation in the emergency department setting. [5]
The atypical antipsychotics (AAP), also known as second generation antipsychotics (SGAs) and serotonin–dopamine antagonists (SDAs), [1] [2] are a group of antipsychotic drugs (antipsychotic drugs in general are also known as tranquilizers and neuroleptics, although the latter is usually reserved for the typical antipsychotics) largely introduced after the 1970s and used to treat psychiatric ...
Individuals may MUA antipsychotics for various reasons, including recreational purposes, self-medication, or attempting to alter their mental or emotional state.The most common forms of antipsychotic abuse may include non-prescribed use, which involves the use of antipsychotic medications without a valid legal prescription or the absence of medical supervision.
A chemical restraint is a form of medical restraint in which a drug is used to restrict the freedom or movement of a patient or in some cases to sedate the patient. Chemical restraint is used in emergency, acute, and psychiatric settings to perform surgery or to reduce agitation, aggression or violent behaviours; [a] it may also be used to control or punish unruly behaviours. [2]
Haloperidol decanoate is provided in the form of 50 or 100 mg/mL oil solution of sesame oil and benzyl alcohol in ampoules or pre-filled syringes. [ 6 ] [ 7 ] [ 9 ] Its elimination half-life after multiple doses is 21 days.
The most common typical antipsychotics associated with EPS are haloperidol and fluphenazine. [4] Atypical antipsychotics have lower D2 receptor affinity or higher serotonin 5-HT2A receptor affinity which lead to lower rates of EPS. [5] Other anti-dopaminergic drugs, like the antiemetic metoclopramide, can also result in extrapyramidal side ...