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Elastin-like polypeptides (ELPs) are synthetic biopolymers with potential applications in the fields of cancer therapy, tissue scaffolding, metal recovery, and protein purification. For cancer therapy, the addition of functional groups to ELPs can enable them to conjugate with cytotoxic drugs. [ 1 ]
Multipotent adult stem cells have the capacity to be self-renewing and give rise to different cell types. Stem cells give rise to progenitor cells, which are cells that are not self-renewing, but can generate several types of cells. The extent of stem cell involvement in cutaneous (skin) wound healing is complex and not fully understood.
Elastin is a protein encoded by the ELN gene in humans and several other animals. Elastin is a key component in the extracellular matrix of gnathostomes (jawed vertebrates). [ 5 ] It is highly elastic and present in connective tissue of the body to resume its shape after stretching or contracting. [ 6 ]
Skin elastosis causes Condition Distinctive features Histopathology Actinic elastosis (most common, also called solar elastosis) Elastin replacing collagen fibers of the papillary dermis and reticular dermis: Elastosis perforans serpiginosa: Degenerated elastic fibers and transepidermal perforating canals (arrow in image points at one of them) [18]
The primary cause of skin cancer is prolonged exposure to ultraviolet (UV) radiation from the sun or tanning devices. Skin cancer is the most commonly diagnosed form of cancer in humans. [11] [12] [13] There are three main types of skin cancers: basal-cell skin cancer (BCC), squamous-cell skin cancer (SCC) and melanoma. [1]
After eighty-two days of consecutive injections the defect regenerated to normal tissue. [4] [5] In 2016, scientists could transform a skin cell into any other tissue type via the use of drugs. [6] The technique was noted as safer than genetic reprogramming which, in 2016, was a concern medically. [6]