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This is because Shiga toxin is usually taken in with contaminated food or water. [citation needed] The bacterial Shiga toxin can be used for targeted therapy of gastric cancer, because this tumor entity expresses the receptor of the Shiga toxin. For this purpose an unspecific chemotherapeutical is conjugated to the B-subunit to make it specific.
The verocytotoxin (shiga-like toxin) can directly damage renal and endothelial cells. Thrombocytopenia occurs as platelets are consumed by clotting. Hemolytic anemia results from intravascular fibrin deposition, increased fragility of red blood cells, and fragmentation.
Escherichia coli O157:H7 is a serotype of the bacterial species Escherichia coli and is one of the Shiga-like toxin–producing types of E. coli.It is a cause of disease, typically foodborne illness, through consumption of contaminated and raw food, including raw milk and undercooked ground beef.
Escherichia coli O121 is a pathogenic serotype of Escherichia coli, [1] associated with Shiga toxin, intestinal bleeding, and hemolytic-uremic syndrome (HUS). [2] HUS, if left untreated, can lead to kidney failure. [citation needed]
The deactivated exotoxins are called toxoids and they are not harmful to somatic cells. An exotoxin is a toxin secreted by bacteria . [ 1 ] An exotoxin can cause damage to the host by destroying cells or disrupting normal cellular metabolism .
The pathogen responsible was found to be an EAEC O104:H4 strain which was lysogenized by a Shiga toxin encoding phage (typically associated with Shiga toxin-producing Escherichia coli, which often encode the adhesin intimin). [7] [8] The putative cause of the outbreak were sprouted fenugreek seeds. [9]
Call Me Irresponsible is the fifth studio album by Canadian singer Michael Bublé.Released on May 1, 2007 via 143 and Reprise Records, it was produced by David Foster, Humberto Gatica, and Bob Rock.
"Home" is a song by Canadian singer Michael Bublé, and released on January 24, 2005, as the first single from his fourth studio album, It's Time. The song was written by Bublé, along with co-writers Alan Chang and Amy Foster-Gillies .