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Signs and symptoms of Huntington's disease most commonly become noticeable between the ages of 30 and 50 years, but they can begin at any age [4] and present as a triad of motor, cognitive, and psychiatric symptoms. [19] When developed in an early stage, it is known as juvenile Huntington's disease. [20]
The film begins at a dinner party. Filmmaker and actress Marianna Palka, 33 years old, is joined by friends in anticipation of the genetic testing results she will receive the next day, revealing whether or not she has inherited the presently untreatable neurodegenerative illness, Huntington's disease, from her father, who has the illness.
Though her parents divorced in 1962, her mother's diagnosis of Huntington's disease late in the 1960s became a central research focus of the family. [3] Wexler taught at Sonoma State University from 1972 to 1982. She served as a visiting professor of history at multiple American universities and received a Guggenheim Fellowship in 1999. [2]
Huntington's disease is an autosomal dominant disorder, inherited from Carol Carr's husband, Hoyt Scott. Hoyt, a factory worker, had lost a sister to the disease as well as a brother, who committed suicide after being diagnosed. Hoyt's condition deteriorated and he died unable to move, swallow, or speak in 1995.
Huntington's disease affects females and males differently. Females have faster disease progression, and display symptoms with fewer trinucleotide repeats. [46] [47] About two times more women than men have unipolar clinical depression [13] (although bipolar disorder appears to affect both sexes equally). [48] [49]
Huntington's disease (HD) is a polyglutamine disorder based on an expanded CAG triplet repeat [9] leading to cerebral and striatal neurodegeneration. [10] Potential sex differences concerning the age of onset and the course of the disease are poorly defined, as the difficulties of matching female and male HD patients regarding their CAG repeat ...