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Shiga-toxin directly activates the alternative complement pathway and also interferes with complement regulation by binding to complement factor H, an inhibitor of the complement cascade. Shiga-toxin causes complement-mediated platelet, leukocyte, and endothelial cell activation, resulting in systemic hemolysis, inflammation and thrombosis.
This is because Shiga toxin is usually taken in with contaminated food or water. [citation needed] The bacterial Shiga toxin can be used for targeted therapy of gastric cancer, because this tumor entity expresses the receptor of the Shiga toxin. For this purpose an unspecific chemotherapeutical is conjugated to the B-subunit to make it specific.
The verocytotoxin (shiga-like toxin) can directly damage renal and endothelial cells. Thrombocytopenia occurs as platelets are consumed by clotting. Hemolytic anemia results from intravascular fibrin deposition, increased fragility of red blood cells, and fragmentation.
Escherichia coli O157:H7 is a serotype of the bacterial species Escherichia coli and is one of the Shiga-like toxin–producing types of E. coli.It is a cause of disease, typically foodborne illness, through consumption of contaminated and raw food, including raw milk and undercooked ground beef.
Women are twice as likely to have an eating disorder in their 40s as to have breast cancer, but midlife eating disorders are under-researched and overlooked. This Menopause Side Effect Was Overlooked.
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E. coli shiga toxin type-2: Setrusumab [26] mab: human: sclerostin (SOST) Sevirumab: human: cytomegalovirus: cytomegalovirus infection Sibrotuzumab: mab: humanized: FAP (gene) (FAP) cancer SGN-CD19A: mab: humanized: CD19: acute lymphoblastic leukemia and B-cell non-Hodgkin lymphoma SHP647: human: mucosal addressin cell adhesion molecule: Crohn ...
[2] [3] This classification, while fairly exhaustive, is not the only system used. Other systems for classifying or identifying toxins include: By organism generating the toxin; By organism susceptible to the toxin; By secretion system used to release the toxin (for example, toxic effectors of type VI secretion system)