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The combination of light and oxygen brings oxidative stress, and RPE has many mechanisms to cope with it. Epithelial transport: As mentioned above, RPE compose the outer blood–retinal barrier, the epithelia has tight junctions between the lateral surfaces and implies an isolation of the inner retina from the systemic influences. This is ...
Relative afferent pupillary defect OD Right eye (oculus dexter) Ret. Retinoscopy RHyperT Right hypertropia RHypoT or RHT Right hypotropia RNFL Retinal nerve fibre layer RPE Retinal pigment epithelium RSOT Right esotropia Rx Prescription SE Spherical Equivalent: SLE Slit lamp examination SLM Slit lamp microscope EP Esophoria: ET Esotropia: Supp.
In AMD there is a progressive accumulation of characteristic yellow deposits, called drusen (buildup of extracellular proteins and lipids), in the macula (a part of the retina), between the retinal pigment epithelium and the underlying choroid. This accumulation is believed to damage the retina over time.
A retrospective series of 20 patients over 10 to 21 years showed deterioration of vision in more than 84% of eyes, either due to intra-retinal edema and serous retinal detachment (Type 1) or retinal pigment epithelium (RPE) scar formation or neovascularization (Type 2).
Elschnig spots are commonly caused by acute hypertensive events of the choroidal vascular system, mostly in the young, because their system of vessels is not ready to handle the changes in blood pressure.
Retinal detachment is a condition where the retina pulls away from the tissue underneath it. [1] [2] [3] It may start in a small area, but without quick treatment, it can spread across the entire retina, leading to serious vision loss and possibly blindness. [4] Retinal detachment is a medical emergency that requires surgery. [2] [3]
Recently, central serous chorioretinopathy has been understood to be part of the pachychoroid spectrum. [5] [6] In pachychoroid spectrum disorders, of which CSR represents stage II, the choroid, the highly vascularized layer below the retina, is thickened and congested with increased blood vessel diameter, especially in the deep choroid (the so-called Haller's layer).
Retinal pigment epithelium-specific 65 kDa protein (also known as RPE65) is a retinoid isomerohydrolase enzyme of the vertebrate visual cycle. [5] [6] RPE65 is expressed in the retinal pigment epithelium (RPE, a layer of epithelial cells that nourish the photoreceptor cells) and is responsible for the conversion of all-trans-retinyl esters to 11-cis-retinol during phototransduction.