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For example, in standard treatment of ovarian cancer, paclitaxel is given at 175 mg/m 2 body surface every three weeks. In dose dense therapy paclitaxel is given at 50–80 mg/m 2 every week (150–240 mg/m 2 in 3-weeks). [2]
These may include chemotherapy given in the dose dense fashion i.e. 2-weekly instead of 3-weekly or TAC chemotherapy (see above). [ 10 ] In women with operable early breast cancer, taxane-containing adjuvant chemotherapy regimens have been found to improve overall survival and disease-free survival.
[12] [11] Paclitaxel is in the taxane family of medications. [13] It works by interference with the normal function of microtubules during cell division. [11] Paclitaxel was isolated in 1971 from the Pacific yew and approved for medical use in 1993. [14] [15] It is on the World Health Organization's List of Essential Medicines. [16]
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Because of the reduced toxicity, dose-adjusted patients were able to be treated for longer periods of time. [23] BSA-dosed people were treated for a total of 680 months while people in the dose-adjusted group were treated for a total of 791 months. [23] Completing the course of treatment is an important factor in achieving better treatment ...
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Protein-bound paclitaxel, also known as nanoparticle albumin–bound paclitaxel or nab-paclitaxel, is an injectable formulation of paclitaxel used to treat breast cancer, lung cancer and pancreatic cancer, among others. Paclitaxel kills cancer cells by preventing the normal breakdown of microtubules during cell division.