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An oocyte is produced in a female fetus in the ovary during female gametogenesis. The female germ cells produce a primordial germ cell (PGC), which then undergoes mitosis, forming oogonia. During oogenesis, the oogonia become primary oocytes. An oocyte is a form of genetic material that can be collected for cryoconservation.
Until the preovulatory stage, the follicle contains a primary oocyte that is arrested in prophase of meiosis I. During the late preovulatory stage, the oocyte continues meiosis and becomes a secondary oocyte, arrested in metaphase II. (a) The maturation of a follicle is shown in a clockwise direction proceeding from the primordial follicles.
The primary oocyte is defined by its process of ootidogenesis, which is meiosis. [2] It has duplicated its DNA, so that each chromosome has two chromatids, i.e. 92 chromatids all in all (4C). When meiosis I is completed, one secondary oocyte and one polar body is created. Primary oocytes have been created in late fetal life.
The primary follicle has oocyte-lining cells that go from floor to cubic and begin to proliferate, increasing the metabolic activity of the oocyte and follicular cells, which release glycoproteins and proteoglycans acids that will form the zona pellucida, which accompany the installation. In the preantral secondary follicle, internal and ...
The secondary oocyte undergoes meiotic division II and that results in the formation of a second small polar body and a large mature egg, both being haploid cells. The polar bodies degenerate. [12] Oocyte maturation stands by at metaphase II in most vertebrates. During ovulation, the arrested secondary oocyte leaves the ovary and matures ...
This is known as the primary oocyte. Human females are born with all the primary oocytes they will ever have. [10] Starting at puberty the process of meiosis can complete resulting in the secondary oocyte and the first polar body. [10] The secondary oocyte can later be fertilized with the male sperm.
During oogenesis, the oogonia become primary oocytes. Oocytes (immature ova) residing in the primordial follicle of the ovary are in a non-growing prophase arrested state, but have the capacity to undergo highly efficient homologous recombinational repair of DNA damages including double-strand breaks. [1]
Pig oocyte surrounded by granulosa cells. Fluorescence microscopy, colored with DAPI . A granulosa cell or follicular cell is a somatic cell of the sex cord that is closely associated with the developing female gamete (called an oocyte or egg) in the ovary of mammals .