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CA-125 was initially detected using the murine monoclonal antibody designated OC125. Robert Bast , Robert Knapp and their research team first isolated this monoclonal antibody in 1981. [ 28 ] The protein was named "cancer antigen 125" because OC125 was the 125th antibody produced against the ovarian cancer cell line that was being studied.
A number of prokaryotic K Ca channels have been described, both structurally and functionally. All are either gated by calcium or other ligands and are homologous to the human K Ca channels, in particular the K Ca 1.1 gating ring. These structures have served as templates for ligand gating.
The US Institute of Medicine (IOM) established Recommended Dietary Allowances (RDAs) for calcium in 1997 and updated those values in 2011. [6] See table. The European Food Safety Authority (EFSA) uses the term Population Reference Intake (PRIs) instead of RDAs and sets slightly different numbers: ages 4–10 800 mg, ages 11–17 1150 mg, ages 18–24 1000 mg, and >25 years 950 mg. [10]
after rehydration, a loop diuretic such as furosemide can be given to permit continued large volume intravenous salt and water replacement while minimizing the risk of blood volume overload and pulmonary oedema. In addition, loop diuretics tend to depress calcium reabsorption by the kidney thereby helping to lower blood calcium levels
A calcium channel is an ion channel which shows selective permeability to calcium ions. It is sometimes synonymous with voltage-gated calcium channel, [1] which are a type of calcium channel regulated by changes in membrane potential.
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The most abundant isotope, 40 Ca, as well as the rare 46 Ca, are theoretically unstable on energetic grounds, but their decay has not been observed. Calcium also has a cosmogenic isotope, 41 Ca, with half-life 99,400 years. Unlike cosmogenic isotopes that are produced in the air, 41 Ca is produced by neutron activation of 40 Ca. Most of its ...
When a Ca 2+ influx occurs, cross bridges form between myosin and actin leading to the contraction of the muscle fibers. Influxes may occur from extracellular Ca 2+ diffusion via ion channels. This can lead to three different results. The first is a uniform increase in the Ca 2+ concentration throughout the cell. This is responsible for ...