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4,4′-Dihydroxybenzophenone is prepared by the rearrangement of p-hydroxyphenylbenzoate: HOC 6 H 4 CO 2 C 6 H 5 → (HOC 6 H 4) 2 CO. Alternatively, p-hydroxybenzoic acid can be converted to p-acetoxybenzoyl chloride. This acid chloride reacts with phenol to give, after deacetylation, 4,4′-dihydroxybenzophenone.
Sivifene (INN, USAN; developmental code name A-007) is a small-molecule antineoplastic agent and immunomodulator that was under development in the 2000s by Tigris Pharmaceuticals (now Kirax Corporation) as a topical treatment for cutaneous cancer metastases.
The scientists analyzed blood, urine, feces, and tissue samples and found three metabolites: 2,4-dihydroxybenzophenone (DHB), 2,2-dihydroxy-4-methoxybenzophenone (DHMB) and 2,3,4-trihydroxybenzophenone (THB). [28] [29] To form DHB the methoxy functional group undergoes O-dealkylation; to form THB the same ring is hydroxylated. [27]
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There are three structural isomers: 1,2-dihydroxybenzene (the ortho isomer) is commonly known as catechol, 1,3-dihydroxybenzene (the meta isomer) is commonly known as resorcinol, and 1,4-dihydroxybenzene (the para isomer) is commonly known as hydroquinone. [1]
[4] [1] [5] [6] [7] Sivifene (A-007) was initially thought to be a SERM due to its structural similarity to tamoxifen but it was subsequently found not to bind to the estrogen receptor (ER). [8] Tesmilifene (DPPE; YMB-1002, BMS-217380-01) is also structurally related to tamoxifen but similarly does not bind to the ER and is not a SERM. [9] [10]
This strong market position generates substantial cash flows that support shareholder returns. Turning to the specifics, the pharmaceutical giant offers investors a 4.3% dividend yield backed by a ...
2,4-Dihydroxybenzaldehyde or β-resorcylaldehyde is a phenolic aldehyde, a chemical compound with the formula C 7 H 6 O 3. It is an isomer of protocatechuic aldehyde (3,4-dihydroxybenzaldehyde). References