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Pemivibart, sold under the brand name Pemgarda, is a monoclonal antibody medication authorized for the pre-exposure prophylaxis (prevention) of COVID‑19. [4] Pemivibart was developed by Invivyd. [3] [5] The US Food and Drug Administration (FDA) issued an emergency use authorization for pemivibart in March 2024. [4] [5]
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The potential emergence of a SARS-CoV-2 variant that is moderately or fully resistant to the antibody response elicited by the COVID-19 vaccines may necessitate modification of the vaccines. [451] The emergence of vaccine-resistant variants is more likely in a highly vaccinated population with uncontrolled transmission. [ 452 ]
A benefit of casirivimab and imdevimab treatment has not been shown in people hospitalized due to COVID‑19. [9] Monoclonal antibodies, such as casirivimab and imdevimab, may be associated with worse clinical outcomes when administered to hospitalized people with COVID‑19 requiring high flow oxygen or mechanical ventilation. [9]
People at considerable risk of developing severe Covid-19, ... there’s growing evidence that people with weakened immune systems may not be protected after vaccination. Monoclonal antibody ...
The WHO recommendations on which medications should or should not be used to treat Covid-19 are continuously updated. As of July 2022, WHO strongly recommended for non-severe cases nirmatrelvir and ritonavir , and recommended conditionally Molnupiravir , Sotrovimab and Remdesivir .
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