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Melatonin's potential to regulate weight gain is posited to involve its inhibitory effect on leptin, a hormone that serves as a long-term indicator of the body's energy status. [31] [32] Leptin is important for regulating energy balance and body weight by signaling satiety and reducing food intake.
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Melatonin is also available as an over-the-counter dietary supplement in many countries. It is available in both immediate-release and less commonly prolonged-release forms. The compound is available in supplements at doses ranging from 0.3 mg to 10 mg or more. It is also possible to buy raw melatonin powder by the weight. [39]
Weight gain. Poor sleep can disrupt hormones involved in appetite regulation, which can trigger food cravings that may impede weight loss goals and increase the risk of obesity. ... Melatonin is ...
Agomelatine acts as a highly potent and selective melatonin MT 1 and MT 2 receptor agonist (K i = 0.1 nM and 0.12 nM, respectively) and also as a relatively weak serotonin 5-HT 2B and 5-HT 2C receptor antagonist (K i = 660 nM and 631 nM, respectively; ~6,000-fold lower than for the melatonin receptors).
The popular sleep aid can have side effects.