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Phenibut is used in Russia, Ukraine, Belarus and Latvia as a pharmaceutical drug to treat anxiety and to improve sleep (e.g., in the treatment of insomnia). [5] [6] It is also used for various other indications, including the treatment of asthenia, depression, alcoholism, alcohol withdrawal syndrome, post-traumatic stress disorder, stuttering, tics, vestibular disorders, Ménière's disease ...
The drug is a GABA analogue and is closely related to baclofen (β-(4-chlorophenyl)-GABA), tolibut (β-(4-methylphenyl)-GABA), and phenibut (β-phenyl-GABA). [1] It is less potent as a GABA B receptor agonist than baclofen but more potent than phenibut.
Phenibut (Anvifen, Fenibut, Noofen) is an anxiolytic [42] used in Russia. [43] Phenibut is a GABA B receptor agonist , [ 42 ] as well as an antagonist at α 2 δ subunit -containing voltage-dependent calcium channels (VDCCs), similarly to gabapentinoids like gabapentin and pregabalin . [ 44 ]
Glufimet (dimethyl 3-phenylglutamate hydrochloride) – experimental drug related to phenibut; Glutamic acid (glutamate) – neurotransmitter; Homotaurine (tramiprosate) – GABA A receptor agonist, GABA B receptor antagonist; Hopantenic acid (N-pantoyl-GABA) – central nervous system depressant used in Russia
The truth is, most things aren't actually all that bad for you if you take them in moderation. Prepare to rejoice and check out the round-up gallery above for 10 supposedly bad things that are ...
Higher levels of omega-6 fatty acids often found in ultraprocessed foods may interfere with the immune system’s fight against cancer cells, a new study says.
In one study, the affinity (K i) values of gabapentinoids for the α 2 δ subunit expressed in rat brain were found to be 0.05 μM for gabapentin, 23 μM for (R)-phenibut, 39 μM for (S)-phenibut, and 156 μM for baclofen. [9] Their affinities (K i) for the GABA B receptor were >1 mM for gabapentin, 92 μM for (R)-phenibut, >1 mM for (S)-phenibut.
If you have a smartwatch or fitness tracker band that contains fluoroelastomer, Alan says there’s no need to panic. “But it is good to be aware of cumulative exposure,” she says.