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A steady-state plasma level of dofetilide is achieved in 2–3 days. 80% of dofetilide is excreted by the kidneys, so the dose of dofetilide should be adjusted in individuals with chronic kidney disease, based on creatinine clearance. In the kidneys, dofetilide is eliminated via cation exchange (secretion).
Bictegravir should not be used with dofetilide and rifampin. [16] Use of dofetilide with bictegravir increases the concentration of dofetilide, which can lead to life-threatening events. [ 16 ] Concomitant use of bictegravir and rifampin causes significant interactions because of an effect rifampin has on bictegravir. [ 16 ]
A variety of living things serve as models in biological research, such as in genetics, and in drug testing. Until the 19th century, plants yielded most of the medicinal drugs in common use, as described in the 1st century by Dioscorides. Plants are the source of many psychoactive drugs, some such as coca known to have been used for thousands ...
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E-4031 blocks hERG-type potassium channels [5] [6] by binding to the open channels. [7] Its structural target within the hERG-channel is unclear, but some other methanesulfonanilide class III antiarrhythmic drugs are known to bind to the S6 domain or C-terminal of the hERG-channel.
It is used in physiological and pharmacological research as an inhibitor of sympathetic transmission. Its mechanism of action is the inhibition of neurotransmitter release from sympathetic nerve terminals, both by the inhibition of action potentials in the nerve terminals and by other mechanisms. [ 8 ]
Safinamide, sold under the brand name Xadago, is a medication used as treatment for Parkinson's disease with "off" episodes; it has multiple modes of action, including the inhibition of monoamine oxidase B. [4] [5] [7] It was approved in the European Union in February 2015, [4] in the United States in March 2017, [5] and in Canada in January ...
This article contains a list of useful plants, meaning a plant that has been or can be co-opted by humans to fulfill a particular need. Rather than listing all plants on one page, this page instead collects the lists and categories for the different ways in which a plant can be used; some plants may fall into several of the categories or lists ...