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Aciclovir has a high distribution rate; protein binding is reported to range from 9 to 33%. [49] The elimination half-life (t 1/2) of aciclovir depends according to age group; neonates have a t 1/2 of 4 hours, children 1–12 years have a t 1/2 of 2–3 hours whereas adults have a t 1/2 of 3 hours. [3]
Valaciclovir is a prodrug, an esterified version of aciclovir that has greater oral bioavailability (about 55%) than aciclovir. [1] It is converted by esterases to the active drug, aciclovir, and the amino acid valine via hepatic first-pass metabolism.
Acyclovir (Aciclovir) Herpes Simplex, chickenpox, [2] varicella zoster virus: GSK: guanosine analogue RTI 1981 Adefovir: Hepatitis B [3] Gilead Sciences RTI 2002 , 2003 Amantadine: Influenza: Influenza A virus M2 proton channel antagonist 1966 Ampligen: Avian Influenza: Immunomodulatory double-stranded RNA: 2016 Amprenavir (Agenerase) HIV
A new survey found that 1 in 5 adults “who say they have no personal or family history of heart attack or stroke,” reported “routinely” taking a low-dose aspirin
Brivudine is used for the treatment of herpes zoster in adult patients. It is taken orally once daily, in contrast to aciclovir, valaciclovir and other antivirals. [1] A study has found that it is more effective than aciclovir, but this has been disputed because of a possible conflict of interest on part of the study authors.
Purine analogues of guanine: Aciclovir, Famciclovir, Ganciclovir, Penciclovir, Valaciclovir, Valganciclovir; Vidarabine; Pyrimidine analogues of uridine: Idoxuridine, Trifluridine; Brivudine; Mutations in the gene coding thymidine kinase in herpes viruses can endow the virus with resistance to aciclovir.
Jon Hamm says he will be "forever grateful" to Saturday Night Live creator Lorne Michaels for his prolific career.. Speaking with reporters following his crowning as the 2025 Hasty Pudding Man of ...
A tablet can be formulated to deliver an accurate dosage to a specific site in the body; it is usually taken orally, but can be administered sublingually, buccally, rectally or intravaginally. The tablet is just one of the many forms that an oral drug can take such as syrups, elixirs, suspensions, and emulsions.