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Pravastatin, sold under the brand name Pravachol among others, is a statin medication, used for preventing cardiovascular disease in those at high risk and treating abnormal lipids. [5] It is suggested to be used together with diet changes, exercise, and weight loss. [ 5 ]
Statins with shorter half-lives are more effective when taken in the evening, so their peak effect occurs when the body's natural cholesterol production is at its highest. A recent meta-analysis suggested that statins with longer half-lives, including atorvastatin, may also be more effective at lowering LDL cholesterol if taken in the evening. [40]
Statins may be less effective in reducing LDL cholesterol in people with familial hypercholesterolemia, especially those with homozygous deficiencies. [53] These people have defects usually in either the LDL receptor or apolipoprotein B genes, both of which are responsible for LDL clearance from the blood. [ 54 ]
Congenital defects. Having problems with your heart from birth. Genetics. Having genes associated with cardiovascular disease. Other risk factors for cardiovascular disease include: High blood ...
Lovastatin is contraindicated during pregnancy (Pregnancy Category X); it may cause birth defects such as skeletal deformities or learning disabilities. Owing to its potential to disrupt infant lipid metabolism, lovastatin should not be taken while breastfeeding. [11] Patients with liver disease should not take lovastatin. [12]
For people with healthy cholesterol levels, eating a moderate amount of dairy products (up to 200 grams per day), whether low or full-fat, may not negatively affect their heart disease risk. In ...
Pregnancy must be avoided while on simvastatin due to potentially severe birth defects. Patients cannot breastfeed while on simvastatin due to potentially disrupting the infant's lipid metabolism. [17] High doses of simvastatin are also contraindicated with the widely used antihypertensive amlodipine. [18]
Statins can be used in combination with lifestyle changes to help keep cholesterol in a healthy range. For example, people may minimize their saturated fat intake and increase their physical ...