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The G s alpha subunit slowly catalyzes the hydrolysis of GTP to GDP, which in turn deactivates the G s protein, shutting off the cAMP pathway. The pathway may also be deactivated downstream by directly inhibiting adenylyl cyclase or dephosphorylating the proteins phosphorylated by PKA. Molecules that inhibit the cAMP pathway include:
Pathway resources and types of pathway analysis using databases like KEGG, Reactome and WikiPathways. [1]Pathway is the term from molecular biology for a curated schematic representation of a well characterized segment of the molecular physiological machinery, such as a metabolic pathway describing an enzymatic process within a cell or tissue or a signaling pathway model representing a ...
[[Category:Signaling pathway templates]] to the <includeonly> section at the bottom of that page. Otherwise, add <noinclude>[[Category:Signaling pathway templates]]</noinclude> to the end of the template code, making sure it starts on the same line as the code's last character.
Please feel free to edit and update the pathway content at WikiPathways. Your changes will be reflected here when the template is regenerated. The collaborative design of this template, which is actually a set of nested templates with an image map at the core, was initially proposed and refined in collaboration with Gene Wiki and MCB. Please ...
The signal transduction component labeled as "MAPK" in the pathway was originally called "ERK," so the pathway is called the MAPK/ERK pathway. The MAPK protein is an enzyme, a protein kinase that can attach phosphate to target proteins such as the transcription factor MYC and, thus, alter gene transcription and, ultimately, cell cycle progression.
This page is the template for the metabolic pathways template. This template should be used to illustrate the general 'shape' of metabolism within the cell . This template is part of the Metabolic Pathways task force .