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Micro-mass cultures of C3H-10T1/2 cells at varied oxygen tensions stained with Alcian blue. A commonly applied definition of tissue engineering, as stated by Langer [3] and Vacanti, [4] is "an interdisciplinary field that applies the principles of engineering and life sciences toward the development of biological substitutes that restore, maintain, or improve [Biological tissue] function or a ...
The decellularized liver matrix (DLM)-gelatin methacryloyl (GelMA)-based biomimetic liver tumor-on-a-chip proved to be a suitable design for further anti-tumor studies. [70] Zhou et al. analyzed alcohol injures on the hepatocytes and the signaling and recovery. [74] The liver-on-a-chip has shown its great potential for liver-related research.
An artificial organ is a human-made organ device or tissue that is implanted or integrated into a human – interfacing with living tissue – to replace a natural organ, to duplicate or augment a specific function or functions so the patient may return to a normal life as soon as possible. [1]
Organ culture is the cultivation of either whole organs or parts of organs in vitro. [1] It is a development from tissue culture methods of research, as the use of the actual in vitro organ itself allows for more accurate modelling of the functions of an organ in various states and conditions.
Takeaways * Scientists have made progress growing human liver in the lab. * The challenge has been to direct stems cells to grow into a mature, functioning adult organ. * This study shows that ...
A liver support system or diachysis is a type of therapeutic device to assist in performing the functions of the liver. Such systems focus either on removing the accumulating toxins (liver dialysis), or providing additional replacement of the metabolic functions of the liver through the inclusion of hepatocytes to the device (bioartificial liver device).
A decellularized aortic homograft. Decellularization (also spelled decellularisation in British English) is the process used in biomedical engineering to isolate the extracellular matrix (ECM) of a tissue from its inhabiting cells, leaving an ECM scaffold of the original tissue, which can be used in artificial organ and tissue regeneration.
A major technology of regenerative medicine is tissue engineering, [2] which has variously been defined as "an interdisciplinary field that applies the principles of engineering and the life sciences toward the development of biological substitutes that restore, maintain, or improve tissue function", or "the creation of new tissue by the ...