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Heat shock proteins induced by the HSR can help prevent protein aggregation that is associated with common neurodegenerative diseases such as Alzheimer's, Huntington's, or Parkinson's disease. [8] The diagram depicts actions taken when a stress is introduced to the cell. Stress will induce HSF-1 and cause proteins to misfold.
In the cytosol, the heat shock response (HSR) manages the unfolded proteins through heat shock factor 1 (HSF1). HSF-1 is a transcription factor that, upon increases in unfolded cytosolic proteins, will trimerize and enter the nucleus to upregulate the expression of heat shock proteins (HSPs) that will act as protein folding chaperones .
Health services research (HSR) became a burgeoning field in North America in the 1960s, when scientific information and policy deliberation began to coalesce. [1] Sometimes also referred to as health systems research or health policy and systems research (HPSR), HSR is a multidisciplinary scientific field that examines how people get access to health care practitioners and health care services ...
High-Speed Research Program, a 1990–1999 NASA supersonic jet program; Hisar Junction railway station, in Haryana, India; Historic Sportscar Racing, an American historic motorsport series; Holyoke Street Railway, a former transit system in western Massachusetts; Hot Springs Municipal Airport, South Dakota, US; Mitsubishi HSR, a concept car
Aside from these models, several studies suggest other processes for DM formation such as through the breakdown of a homogeneously staining region (HSR) following cell fusion, [5] through chromosomal breaks due to hypoxia induced activation of fragile sites, [6] or reduction in the level of DNA methylation.
An HSR is one type of change in a chromosome's structure which is frequently observed in the nucleus of human cancer cells. In the region of a chromosome where an HSR occurs, a segment of the chromosome, which presumably contains a gene or genes that give selective advantage to the progression of the cancer, is amplified or duplicated many times.
The developmentally active and heat shock inducible hsromega or hsrω gene in Drosophila produces multiple long non-coding RNA transcripts.This gene is transcriptionally active in almost all cell types of Drosophila and is the most actively induced following heat shock.
A research design that involves multiple measures of the same variable taken on the same or matched subjects either under different conditions or over two or more time periods. [ 1 ] Paired t-test , Wilcoxon signed-rank test