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Papaya extract Carica papaya: Warfarin Damage to GI tract mucous membranes [3] Kava: kava-kava Piper methysticum: Sedatives, sleeping pills, antipsychotics, alcohol [15] Milkvetch: Astragalus: Astragalus may interact with medications that suppress the immune system, such as cyclophosphamide. [24] It may also affect blood sugar levels and blood ...
Bergamottin and dihydroxybergamottin are linear furanocoumarins functionalized with side chains derived from geraniol. They are inhibitors of some isoforms of the cytochrome P450 enzyme, in particular CYP3A4. [2] This prevents oxidative metabolism of certain drugs by the enzyme, resulting in an elevated concentration of drug in the bloodstream.
Analgesic and behavioral effects were reported for 12 hours and plasma samples were analyzed for oxycodone metabolites for 48 hours. Grapefruit juice increased the mean area under the oxycodone concentration-time curve (AUC(0-∞)) by 1.7 fold, the peak plasma concentration by 1.5-fold and the half-life of oxycodone by 1.2-fold as compared to ...
Grapefruit juice contains bergamottin, one of the furanocoumarins which inhibit the metabolism of many drugs, causing multiple side-effects. [21] Grapefruit and grapefruit juice interact with many drugs, resulting in numerous adverse effects including bone marrow suppression, nephrotoxicity, abnormal heart rhythm, rhabdomyolysis, hypotension ...
Dysembryoplastic neuroepithelial tumour (DNT, DNET) is a type of brain tumor.Most commonly found in the temporal lobe, DNTs have been classified as benign tumours. [1] These are glioneuronal tumours comprising both glial and neuron cells and often have ties to focal cortical dysplasia.
Compounds in grapefruit affect a number of drugs, including dextromethorphan, through the inhibition of the cytochrome P450 system in the liver, and can lead to excessive accumulation of the drug which both increases and prolongs effects. Grapefruit and grapefruit juices (especially white grapefruit juice, but also including other citrus fruits ...
Grapefruit seed extract (GSE), also known as citrus seed extract, is a liquid extract derived from the seeds, pulp, and white membranes of grapefruit. [1] GSE is prepared by grinding the grapefruit seed and juiceless pulp, then mixing with glycerin . [ 1 ]
Grape seed extract is sold as a dietary supplement. [6] The US National Center for Complementary and Integrative Health reported that oral administration of grape seed extract (dose and frequency unreported) was well tolerated in people over 14 weeks. [1] Side effects may include itchy scalp, dizziness, headache, and nausea. [1]