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Alendronic acid, sold under the brand name Fosamax among others, is a bisphosphonate medication used to treat osteoporosis and Paget's disease of bone. [4] It is taken by mouth. [ 4 ] Use is often recommended together with vitamin D , calcium supplementation , and lifestyle changes.
More severe side effects include worsening asthma, blocking the ability to recognize low blood sugar, and worsening heart failure. [9] There are concerns that use during pregnancy may be harmful to the baby. [10] Bisoprolol was patented in 1976 and approved for medical use in 1986. [11] It was approved for medical use in the United States in ...
The long side-chain (R 2 in the diagram) determines the chemical properties, the mode of action and the strength of bisphosphonate drugs. The short side-chain (R 1), often called the 'hook', mainly influences chemical properties and pharmacokinetics. See nitrogenous and non-nitrogenous sections in Mechanism of action below.
Other factors such as toxicants can adversely impact bone cells. Infections, chronic or acute, can affect blood flow by inducing platelet activation and aggregation, contributing to a localized state of excess coagulability (hypercoagulability) that may contribute to clot formation (), a known cause of bone infarct and ischaemia.
The F1 driver, meanwhile, was his cool self in a caramel-brown flannel layered under a boxy chocolate-brown workwear-inspired jacket. He went construction-core with his bottoms too: baggy, paint ...
Side chain that is made out of three carbons has proven to be the most ideal length in terms of activity, increasing or decreasing the length of the chain from there has negative effect on biological activity. Alendronate, a common bisphosphonate drug, has a three carbon length side chain for example. [17]
One mom dog who survived being shot four times shortly after giving birth to 11 puppies is making a miraculous recovery thanks to the kindness of generous donors.
DJ Unk, the Atlanta MC known for his early 2000s hits including “Walk It Out” and “2 Step," died after suffering a cardiac arrest this week, according to his wife.