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Aspirin-exacerbated respiratory disease (AERD), also called NSAID-exacerbated respiratory disease (N-ERD) or historically aspirin-induced asthma and Samter's Triad, is a long-term disease defined by three simultaneous symptoms: asthma, chronic rhinosinusitis with nasal polyps, and intolerance of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs).
Asthma is a long-term inflammatory disease of the airways of the lungs. [4] It is characterized by variable and recurring symptoms, reversible airflow obstruction, and easily triggered bronchospasms. [9][10] Symptoms include episodes of wheezing, coughing, chest tightness, and shortness of breath. [3]
Aspirin is also used long-term to help prevent further heart attacks, ischaemic strokes, and blood clots in people at high risk. [10] For pain or fever, effects typically begin within 30 minutes. [10] Aspirin works similarly to other NSAIDs but also suppresses the normal functioning of platelets. [10] One common adverse effect is an upset ...
Max Samter. Max Samter (March 8, 1909 – February 9, 1999) was a German-American immunologist who first extensively studied the triad between asthma, aspirin allergy, and nasal polyps that became known as Samter's triad, now aspirin-exacerbated respiratory disease. [1] Samter was a third generation doctor and obtained medical training in ...
Acute severe asthma. Silent chest, worsening symptoms despite use of medication. [1] Acute severe asthma, also known as status asthmaticus, is an acute exacerbation of asthma that does not respond to standard treatments of bronchodilators (inhalers) and corticosteroids. [2] Asthma is caused by multiple genes, some having protective effect, with ...
The classification organizes the hypersensitivity reactions to NSAIDs into the following five categories: NSAIDs-exacerbated respiratory disease (NERD) is an acute (immediate to several hours) exacerbation of bronchoconstriction and other symptoms of asthma in individuals with a history of asthma and/or nasal congestion, rhinorrhea or other symptoms of rhinitis and sinusitis in individuals ...
The prevalence of asthma increased 75% from 1980 to 1994. Asthma prevalence is 39% higher in African Americans than in Europeans. [126] 5.7 million (about 9.4%). In six- and seven-year-olds asthma increased from 18.4% to 20.9% over five years, during the same time the rate decreased from 31% to 24.7% in 13- to 14-year-olds. Atopic eczema
Beta2-adrenergic agonists, also known as adrenergic β2 receptor agonists, are a class of drugs that act on the β 2 adrenergic receptor. Like other β adrenergic agonists, they cause smooth muscle relaxation. β 2 adrenergic agonists' effects on smooth muscle cause dilation of bronchial passages, vasodilation in muscle and liver, relaxation of ...