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A de novo mutation (DNM) is any mutation or alteration in the genome of an individual organism (human, animal, plant, microbe, etc.) that was not inherited from its parents. This type of mutation spontaneously occurs during the process of DNA replication during cell division. De novo mutations, by definition, are present in the affected ...
Glioblastoma, previously known as glioblastoma multiforme (GBM), is the most aggressive and most common type of cancer that originates in the brain, and has a very poor prognosis for survival. [6][7][8] Initial signs and symptoms of glioblastoma are nonspecific. [1] They may include headaches, personality changes, nausea, and symptoms similar ...
Familial adenomatous polyposis (FAP) is an autosomal dominant inherited condition in which numerous adenomatous polyps form mainly in the epithelium of the large intestine. While these polyps start out benign, malignant transformation into colon cancer occurs when they are left untreated. Three variants are known to exist, FAP and attenuated ...
De novo protein design, the creation of a protein sequence that is not based on existing, natural sequences. De novo protein structure prediction, the prediction of a protein's 3D structure, based only on its sequence. De novo synthesis of complex molecules from simple molecules in chemistry. De novo transcriptome assembly, the method of ...
Nevus (pl.: nevi) is a nonspecific medical term for a visible, circumscribed, chronic lesion of the skin or mucosa. [1] The term originates from nævus, which is Latin for "birthmark"; however, a nevus can be either congenital (present at birth) or acquired. Common terms, including mole, birthmark, and beauty mark, are used to describe nevi ...
Tuberous sclerosis. Tuberous sclerosis complex (TSC) is a rare multisystem autosomal dominant genetic disease that causes non-cancerous tumours to grow in the brain and on other vital organs such as the kidneys, heart, liver, eyes, lungs and skin.
H&E stain. A dysplastic nevus or atypical mole is a nevus (mole) whose appearance is different from that of common moles. In 1992, the NIH recommended that the term "dysplastic nevus" be avoided in favor of the term "atypical mole". [1] An atypical mole may also be referred to as an atypical melanocytic nevus, [2] atypical nevus, B-K mole ...
Vasculogenesis. Vasculogenesis is the process of blood vessel formation, occurring by a de novo production of endothelial cells. [1] It is the first stage of the formation of the vascular network, closely followed by angiogenesis. [2][3]