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Complications of familial atrial fibrillation can occur at any age, although some people with this heart condition never experience any health problems associated with the disorder. Atrial fibrillation is the most common type of sustained abnormal heart rhythm ( arrhythmia ), affecting more than 3 million people in the United States .
For example, a meta-analysis accomplished in 2018 revealed the discovery of 70 new loci associated with atrial fibrillation. It has been identified different variants associated with transcription factor coding-genes, such as TBX3 and TBX5 , NKX2-5 o PITX2 , which are involved in cardiac conduction regulation, in ionic channel modulation and ...
Atrial fibrillation is associated with an increased risk of heart failure, dementia, and stroke. [3] [12] It is a type of supraventricular tachycardia. [14] Atrial fibrillation frequently results from bursts of tachycardia that originate in muscle bundles extending from the atrium to the pulmonary veins. [15]
Situs ambiguus has been linked to family history of malformations [8] [9] and maternal cocaine use, [10] suggesting both genetic and environmental factors play a role. [11] Several genes in the TGF-beta pathway , which controls left-right patterning of visceral organs across the body axis, have been indicated in sporadic and familial cases of ...
Familial hypertrophic cardiomyopathy is inherited as an autosomal dominant trait which is attributed to mutations in one of a number of genes that encode for the sarcomere proteins, and most diagnosed individuals will have an affected parent. Occasionally, both copies of the gene will be defective, a condition that may lead to a more severe ...
A number of risk assessment models incorporating a number of demographic, environmental and clinical risk factors are already shown to elicit reasonable discrimination in case-control studies; it has been proposed that identifying genetic variants that contribute to T2D as for standalone prediction or in conjunction with current risk models can ...
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited genetic disorder that predisposes those affected to potentially life-threatening abnormal heart rhythms or arrhythmias. The arrhythmias seen in CPVT typically occur during exercise or at times of emotional stress, and classically take the form of bidirectional ...
With Atrial fibrillation, or A-fib or AF, signals move around the atria in a completely disorganized way that tends to override the sinus node. Instead of a one big contraction then, you get all these mini contractions that make it just look like the atria are just quivering.
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