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This type of reaction is also called a 1,2-nucleophilic addition. The stereochemistry of this type of nucleophilic attack is not an issue, when both alkyl substituents are dissimilar and there are not any other controlling issues such as chelation with a Lewis acid, the reaction product is a racemate. Addition reactions of this type are numerous.
The most prominent application and impact of the Flippin–Lodge angle has been in the area of chemistry where it was originally defined: in practical synthetic studies of the outcome of carbon-carbon bond-forming reactions in solution. An important example is the aldol reaction, e.g., addition of ketone-derived nucleophiles (enols, enolates ...
An addition reaction is the reverse of an elimination reaction, in which one molecule divides into two or more molecules. For instance, the hydration of an alkene to an alcohol is reversed by dehydration. There are two main types of polar addition reactions: electrophilic addition and nucleophilic addition.
Organostannane addition reactions comprise the nucleophilic addition of an allyl-, allenyl-, or propargylstannane to an aldehyde, imine, or, in rare cases, a ketone. [1] The reaction is widely used for carbonyl allylation .
Nucleophilic conjugate addition is a type of organic reaction. Ordinary nucleophilic additions or 1,2-nucleophilic additions deal mostly with additions to carbonyl compounds. Simple alkene compounds do not show 1,2 reactivity due to lack of polarity , unless the alkene is activated with special substituents .
The reaction product is a primary, secondary or tertiary alcohol. The reaction is similar to the Grignard reaction but the crucial difference is that the organometallic species in the Barbier reaction is generated in situ, whereas a Grignard reagent is prepared separately before addition of the carbonyl compound. [1]
The reaction mechanism for the Johnson–Corey–Chaykovsky reaction consists of nucleophilic addition of the ylide to the carbonyl or imine group. A negative charge is transferred to the heteroatom and because the sulfonium cation is a good leaving group it gets expelled forming the ring.
Vicinal difunctionalization refers to a chemical reaction involving transformations at two adjacent centers (most commonly carbons). This transformation can be accomplished in α,β-unsaturated carbonyl compounds via the conjugate addition of a nucleophile to the β-position followed by trapping of the resulting enolate with an electrophile at the α-position.