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In ADHD, guanfacine is thought to work by strengthening the regulation of attention and behavior by the prefrontal cortex. [ 43 ] [ 18 ] These enhancing effects on prefrontal cortical functions are believed to be due to drug stimulation of post-synaptic α 2A -adrenoceptors on dendritic spines , and are not dependent on activation of pre ...
There is insufficient evidence to determine if sedation caused by caffeine is due to a true paradoxical reaction, or rather from dehydration and sleep deprivation caused by the caffeine. [21] Furthermore, there are no conclusive studies showing a differential effect of caffeine in individuals with ADHD compared to the general population.
Attention deficit hyperactivity disorder management options are evidence-based practices with established treatment efficacy for ADHD.Approaches that have been evaluated in the management of ADHD symptoms include FDA-approved pharmacologic treatment and other pharmaceutical agents, psychological or behavioral approaches, combined pharmacological and behavioral approaches, cognitive training ...
A sedative or tranquilliser [note 1] is a substance that induces sedation by reducing irritability [1] or excitement. [2] They are CNS depressants and interact with brain activity causing its deceleration. Various kinds of sedatives can be distinguished, but the majority of them affect the neurotransmitter gamma-aminobutyric acid (GABA). In ...
Attention deficit hyperactivity disorder (ADHD) [1] is a neurodevelopmental disorder characterized by executive dysfunction occasioning symptoms of inattention, hyperactivity, impulsivity and emotional dysregulation that are excessive and pervasive, impairing in multiple contexts, and developmentally-inappropriate.
The most comprehensive meta-analysis available (19 studies with over 3.9 million participants) found "no statistically significant association between ADHD medications [including methylphenidate] and the risk of cardiovascular event among children and adolescents, young and middle-aged adults, or older adults"; [44] as do other systematic ...