Ads
related to: apoe gene
Search results
Results From The WOW.Com Content Network
The gene, APOE, is mapped to chromosome 19 in a cluster with the apolipoprotein C1 (APOC1) gene and the apolipoprotein C2 (APOC2) gene. The APOE gene consists of four exons and three introns, totaling 3597 base pairs. APOE is transcriptionally activated by the liver X receptor (an important regulator of cholesterol, fatty acid, and glucose ...
The APOE gene contains directions needed to make a protein called apolipoprotein E. Different types of the APOE gene are known to contribute to the development of Alzheimer’s disease.
The ApoE4 genetic variant is associated with the highest risk, while a rare form, ApoE Christchurch, binds weakly to HSPGs and appears to reduce the risk of Alzheimer’s in genetically ...
Apolipoprotein E (apoE) plays an important role in the transport and uptake of cholesterol by way of its high affinity interaction with lipoprotein receptors, including the low-density lipoprotein (LDL) receptor. ApoE is the major lipoprotein in the central nervous system.
APOE associates with high-density lipoproteins (HDL). [12] The gene for APOE is located on chromosome 19 and exhibits polymorphisms in the population defined by three alleles of APOE: 𝜀2, 𝜀3, and 𝜀4. [16] [19] These alleles differ by only two single nucleotide polymorphisms in exon 4, rs429358 and rs7412 (amino-acid position 112 and 158).
We aim to assess ApoE genotype [associated with a heightened Alzheimer’s risk] in our longitudinal study and control for it in our analysis,” said Dolatshahi.
Research from the National Institutes of Health suggests the neuro-protective effects of physical activity might be even bigger for people carrying APOE e4, a gene linked to increased Alzheimer ...
APOE may refer to: Apolipoprotein E , a main apoprotein of the chylomicron, also studied for its involvement in Alzheimer's disease risk Professional Oklahoma Educators , an organization in Oklahoma formerly known as the Association of Professional Oklahoma Educators or APOE