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A telomere (/ ˈ t ɛ l ə m ɪər, ˈ t iː l ə-/; from Ancient Greek τέλος (télos) 'end' and μέρος (méros) 'part') is a region of repetitive nucleotide sequences associated with specialized proteins at the ends of linear chromosomes (see Sequences). Telomeres are a widespread genetic feature most commonly found in eukaryotes.
Telomere shortening does not occur with age in some postmitotic tissues, such as in the rat brain. [35] In humans, skeletal muscle telomere lengths remain stable from ages 23 –74. [ 36 ] In baboon skeletal muscle, which consists of fully differentiated postmitotic cells, less than 3% of myonuclei contain damaged telomeres and this percentage ...
The temporal lobes are a region of the cerebral cortex that is located beneath the Sylvian fissure on both the left and right hemispheres of the brain. [14] Lobes in this cortex are more closely associated with memory and in particular autobiographical memory. [15] The temporal lobes are also concerned with recognition memory.
Telomeres at the end of a chromosome. The relationship between telomeres and longevity and changing the length of telomeres is one of the new fields of research on increasing human lifespan and even human immortality. [1] [2] Telomeres are sequences at the ends of chromosomes that shorten with each cell division and determine the lifespan of ...
Brain at the U.S. National Library of Medicine Medical Subject Headings (MeSH) (view tree for regions of the brain) BrainMaps.org; BrainInfo (University of Washington) "Brain Anatomy and How the Brain Works". Johns Hopkins Medicine. 14 July 2021. "Brain Map". Queensland Health. 12 July 2022.
A series of 10 to >100 kb repeats is located in the normal 4q subtelomere, but FSHD patients have only 1–10 repeat units. This deletion is thought to cause disease owing to a position effect that influences the transcription of nearby genes, rather than through the loss of the repeat array itself.
Rachel Wu, a former rock violinist known as Echo for the indie band the Outside Royalty who got her PhD and became an associate psychology professor at UC Riverside, has found that learning new ...
As the cell divides, the telomeres on the end of a linear chromosome get shorter. The telomeres will eventually no longer be present on the chromosome. This end stage is the concept that links the deterioration of telomeres to aging. Top: Primary mouse embryonic fibroblast cells (MEFs) before senescence. Spindle-shaped.