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  2. Hallmarks of aging - Wikipedia

    en.wikipedia.org/wiki/Hallmarks_of_aging

    Normal aging is associated with telomere shortening in both humans and mice, and studies on genetically modified animal models suggest causal links between telomere erosion and aging. [10] Leonard Hayflick demonstrated that a normal human fetal cell population will divide between 40 and 60 times in cell culture before entering a senescence phase.

  3. Relationship between telomeres and longevity - Wikipedia

    en.wikipedia.org/wiki/Relationship_between...

    Telomeres at the end of a chromosome. The relationship between telomeres and longevity and changing the length of telomeres is one of the new fields of research on increasing human lifespan and even human immortality. [1] [2] Telomeres are sequences at the ends of chromosomes that shorten with each cell division and determine the lifespan of ...

  4. Aging in dogs - Wikipedia

    en.wikipedia.org/wiki/Aging_in_dogs

    Older dogs, similar to this 10-year-old Neapolitan Mastiff, often grow grey hairs on their muzzles, and some dogs grow grey hair all over. Not all dogs gain grey hair when aging. Aging in dogs varies from breed to breed, and affects the dog's health and physical ability. As with humans, advanced years often bring changes in a dog's ability to ...

  5. Evolution of ageing - Wikipedia

    en.wikipedia.org/wiki/Evolution_of_ageing

    New research has also shown that there is an association between telomere shortening and mitochondrial dysfunction. [33] Nevertheless, over-expression of telomerase increases the chances of cancer. If telomeres stay in repair, there is a greater chance of longevity, but there is also more cell division and a greater chance of mutation, which ...

  6. Telomeres in the cell cycle - Wikipedia

    en.wikipedia.org/wiki/Telomeres_in_the_cell_cycle

    This problem makes eukaryotic cells unable to copy the last few bases on the 3' end of the template DNA strand, leading to chromosome—and, therefore, telomereshortening every S phase. [2] Measurements of telomere lengths across cell types at various ages suggest that this gradual chromosome shortening results in a gradual reduction in ...

  7. Telomere - Wikipedia

    en.wikipedia.org/wiki/Telomere

    Critically short telomeres trigger a DNA damage response and cellular senescence. [32] Mice have much longer telomeres, but a greatly accelerated telomere shortening-rate and greatly reduced lifespan compared to humans and elephants. [33] Telomere shortening is associated with aging, mortality, and aging-related diseases in experimental animals.

  8. DNA damage theory of aging - Wikipedia

    en.wikipedia.org/wiki/DNA_damage_theory_of_aging

    Increasing DNA damage with age has been reported in the brains of the mouse, rat, gerbil, rabbit, dog, and human. [13] Rutten et al. [30] showed that single-strand breaks accumulate in the mouse brain with age.

  9. Carnosine - Wikipedia

    en.wikipedia.org/wiki/Carnosine

    Carnosine can increase the Hayflick limit in human fibroblasts, [15] as well as appearing to reduce the telomere shortening rate. [16] Carnosine may also slow aging through its anti-glycating properties (chronic glycolyating is speculated to accelerate aging). [17]