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4-Methylaminorex exists as four stereoisomers : (±)-cis and (±)-trans.The (±)-cis isomers are the form used recreationally.The (±)-cis isomers [racemate (1:1-mixture) of the (4R,5S)-isomer and the enantiomeric (4S,5R)-isomer] generally synthesized from dl-phenylpropanolamine in one step by cyclization with cyanogen bromide (sometimes prepared in situ by reacting sodium cyanide with bromine).
4'-Chloro-4-methylaminorex (4C-MAR, 4'-Cl-4-MAR) is a recreational designer drug from the substituted aminorex family, with stimulant effects. It has reportedly been sold since around 2021 and was first definitively identified in Austria in January 2022.
Users report effects such as increased energy, euphoria, and enhanced sociability, although its potency and duration are considered less intense than similar compounds like mephedrone. Despite its recreational use, 4-MEC poses potential health risks, including cardiovascular strain, neurotoxicity, and dependency.
These side effects are serious and some of them are permanent, and many remain a crucial concern for companies and healthcare professionals and substantial efforts are being encouraged to reduce the potential risks for future antipsychotics through more clinical trials and drug development.
Neurological changes: For many, this can look like having low energy or mood changes. Dr. Castilla notes that some conditions can also be associated with issues around biotin.
Ephedrine (usually as Ephedra extract) was a common ingredient in many pre-workout supplements in the 1990s and early 2000s, sometimes in combination with caffeine and aspirin (the so-called ECA stack), however, following many reports of serious side effects and some deaths, it was banned for use in supplements by the FDA in 2004 throughout the ...