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Donepezil has been tested in other cognitive disorders, including Lewy body dementia, [33] and vascular dementia, [34] but it is not currently approved for these indications. Donepezil has also been found to improve sleep apnea in people with Alzheimer's. [35] It also improves gait in people with mild Alzheimer's. [36]
People with Lewy body dementias who take neuroleptics are at risk for neuroleptic malignant syndrome, a life-threatening illness. [51] There is no evidence to support the use of antipsychotics to treat the Lewy body dementias, [10] and they carry the additional risk of stroke when used in the elderly with dementia. [86]
The first treatment was a cholinesterase inhibitor called donepezil, ... “I’ve seen them help many of my Lewy body patients and in some cases they seem even more helpful than in Alzheimer’s ...
Pages in category "Lewy body dementia" ... Dementia with Lewy Bodies Consortium; Donepezil; K. Kenji Kosaka (psychiatrist) L. Lewy body; Lewy Body Dementia Association;
Lewy body dementia (LBD) is an umbrella term for two similar and common subtypes of dementia: [1] dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD).
Paraoxon and rivastigmine are both acetylcholinesterase inhibitors and butyrylcholinesterase inhibitors. [14] [11] [7]In 2015, the United States Food and Drug Administration's Adverse Event Reporting System database compared rivastigmine to the other ChEI drugs donepezil and galantamine found that rivastigmine was associated with a higher frequency of reports of death as an adverse event.