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The anterolateral system (ALS) is an ascending bundle of fibers in the spinal cord, carried in three main pathways or tracts. [1] The tracts convey pain, [6] temperature (protopathic sensation), and crude touch from the periphery to the brain. The most important of these is the spinothalamic tract. [2]
The tract transmits slow nociceptive/pain information (but thermal, and crude touch information as well) from the spinal cord to reticular formation which in turn relays the information to the thalamus via reticulothalamic fibers as well as to other parts of the brain (as opposed to the spinothalamic tract - the direct pathway of the ...
Cordotomy (or chordotomy) is a surgical procedure that disables selected pain-conducting tracts in the spinal cord, in order to achieve loss of pain and temperature perception. This procedure is commonly performed on patients experiencing severe pain due to cancer or other incurable diseases.
Anterolateral corticospinal tract is a subdivision of the corticospinal tract in the spinal cord. It is formed by approximately 2% of the corticospinal fibers that do not cross to the opposite side of the brainstem in the pyramidal decussation. This tract descends in the lateral white column anterior to the lateral corticospinal tract. [1]
Descending tracts are pathways by which motor signals are sent from upper motor neurons in the brain to lower motor neurons which then directly innervate muscle to produce movement. The anterior corticospinal tract is usually small, varying inversely in size with the lateral corticospinal tract , which is the main part of the corticospinal tract .
This pathway describes the first-order neuron. Aδ fibers serve to receive and transmit information primarily relating to acute pain (sharp, immediate, and relatively short-lasting). This type of pain can result from several classifications of stimulants: temperature-induced, mechanical, and chemical.
The most lateral of the bundles of the anterior nerve roots is generally taken as a dividing line that separates the anterolateral system into two parts. These are the anterior funiculus, between the anterior median fissure and the most lateral of the anterior nerve roots, and the lateral funiculus between the exit of these roots and the posterolateral sulcus.
Diffuse noxious inhibitory controls (DNIC) or conditioned pain modulation (CPM) refers to an endogenous pain modulatory pathway which has often been described as "pain inhibits pain". [1] It occurs when response from a painful stimulus is inhibited by another, often spatially distant, noxious stimulus.