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While lower levels of vitamin B12 are associated with higher BMI and body fat, taking vitamin B12 supplements didn’t change body composition over the long term. More research is needed on the ...
Low levels of vitamin B12 are common, especially in people who don't consume animal products, because animal products are the primary food source for vitamin B12.
Pernicious anemia, or Addison's anemia, is an autoimmune disease which decreases red blood cell count, caused by the body's inability to properly absorb vitamin B12. It can cause diarrhea, pale ...
How fast B 12 levels change depends on the balance between how much B 12 is obtained from the diet, how much is secreted and how much is absorbed. The total amount of vitamin B 12 stored in the body is about 2–5 mg in adults. Around 50% of this is stored in the liver.
The Recommended Dietary Allowance (RDA) for vitamin B12 is 0.9-2.4 μg/day, while the estimated average requirement in the U.S. and Canada is 0.7-2 μg/day. Elderly individuals with plasma vitamin B12 levels below 148 pmol/L are considered severely deficient, and those with levels between 148 and 221 pmol/L are marginally deficient.
It primarily serves to protect cobalamin (Vitamin B12) from acid degradation in the stomach by producing a HC-Vitamin B 12 complex. Once the complex has traveled to the more pH-neutral duodenum, pancreatic proteases degrade haptocorrin, releasing free cobalamin, which now binds to intrinsic factor for absorption by ileal enterocytes.